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Solely a handful of proteins (22) significantly changed abundance between the 25Q-ni, 97Q-ni and 97Q-i samples ( Fig 2B ). None of those had identified protein-protein interactions ( Fig 2C ) and the dataset was enriched with just one Gene Ontology (GO) term (cytoskeleton GO:0005856, Supplementary Information 1). However, several of the proteins have reported roles in Huntington’s disease-related mechanisms.

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