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This revealed galectin-3, which can be an extracellular matrix protein involved in remodelling, as a biomarker of response 82 This protein could be measured in urine and serum, and might be tested in future research as a marker of response to therapy 83 A proposed future strategy to permit the complexities and heterogeneity underlying the pathophysiology of asthma, with quite a few dysregulated molecular pathways to be disentangled, is to utilise unbiased systems biology.
To deal with the elemental query of whether there’s a widespread metastable subproteome that’s more aggregation-inclined underneath any condition of stress on account of protein misfolding, we next sought to assess whether or not stress increased the web insolubility of the proteome by measuring the protein mass concentration in the supernatants earlier than versus after pelleting.
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Additional evidence is that different genes that cause myofibrillar myopathies when mutated, are Desm, and chaperones DnajB6, HspB8, Cryab and Bag3 which recommend these chaperones are important to stabilizing the folded state of Flnc ( Kley et al., 2016 ). We additionally noted Bag3, which additionally co-localizes in stress granules, as one in every of our proteins that change into extra insoluble in no less than three stresses.
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