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As a significant task for this system is to prevent broken and misfolded proteins from accumulating, it has been hypothesized that, when this system turns into unbalanced, proteins can turn out to be liable to misfolding resulting in their mislocalisation and accumulation as aggregates ( Balch et al., 2008 ; Knowles et al., 2014 ; Schneider and Bertolotti, 2015 ). Dysfunctional protein aggregation and protein homeostasis imbalance are central pathological features of widespread neurodegenerative ailments including Alzheimer’s, Parkinson’s, Huntington’s, and motor neuron illnesses ( Balch et al., 2008 ; Bertram and Tanzi, 2005 ; Hipp et al., 2014 ; Radwan et al., 2017 ; Yerbury et al., 2016 ).

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At three days after mating, increased expression of a reporter that replicates the transcriptional regulation and post-translational modification of sterol regulatory factor-binding protein (SREBP) is clear within the posterior midgut (A, A′, quantified in B, p < 0.001,="" mann-whitney="" take="" a="" look="">

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