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Strikingly, nevertheless, methacholine challenge induced only bronchoconstriction and remodelling without inflammation 43 Information from experimental fashions additionally suggest a a lot tighter relationship between airway contraction, lung perform and remodelling than any association between irritation and remodelling 44 In late-onset (grownup) murine models it is changing into increasingly obvious that remodelling can develop regardless of minimal or absent airway irritation forty five Utilizing a genetically susceptible mouse mannequin, with bronchial epithelial overexpression of Smad2 and continual inhalation of ovalbumin, with out peripheral sensitisation, marked AHR and remodelling developed in the absence of airway … Read the restRead More →